Itraconazole Inhibits Enterovirus Replication by Targeting the Oxysterol-Binding Protein

Itraconazole Inhibits Enterovirus Replication by Targeting the Oxysterol-Binding Protein

Itraconazole (ITZ) is a well-known antifungal agent that also has anticancer activity. In this study, we identify ITZ as a broad-spectrum inhibitor of enteroviruses (e.g., poliovirus, coxsackievirus, enterovirus-71, rhinovirus). We demonstrate that ITZ inhibits viral RNA replication by targeting oxy...

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Bibliographic Details
Main Authors: Jeroen R.P.M. Strating, Lonneke van der Linden, Lucian Albulescu, Joëlle Bigay, Minetaro Arita, Leen Delang, Pieter Leyssen, Hilde M. van der Schaar, Kjerstin H.W. Lanke, Hendrik Jan Thibaut, Rachel Ulferts, Guillaume Drin, Nina Schlinck, Richard W. Wubbolts, Navdar Sever, Sarah A. Head, Jun O. Liu, Philip A. Beachy, Maria A. De Matteis, Matthew D. Shair, Vesa M. Olkkonen, Johan Neyts, Frank J.M. van Kuppeveld
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714011218

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http://www.sciencedirect.com/science/article/pii/S2211124714011218

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