Integrated mRNA and miRNA Transcriptomic Analyses Reveals Divergent Mechanisms of Sunitinib Resistance in Clear Cell Renal Cell Carcinoma (ccRCC)

Integrated mRNA and miRNA Transcriptomic Analyses Reveals Divergent Mechanisms of Sunitinib Resistance in Clear Cell Renal Cell Carcinoma (ccRCC)

The anti-angiogenic therapy sunitinib remains the standard first-line treatment for meta static clear cell renal cell carcinoma (ccRCC). However, acquired resistance develops in nearly all responsive patients and represents a major source of treatment failure. We used an integrated miRNA and mRNA tr...

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Bibliographic Details
Main Authors: María Armesto, Maitane Marquez, María Arestin, Peio Errarte, Ane Rubio, Lorea Manterola, Jose I. López, Charles H. Lawrie
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
renal cancer
sunitinib
resistance
miRNA
transcriptome
pathway analysis
Online Access:https://www.mdpi.com/2072-6694/13/17/4401

Internet

https://www.mdpi.com/2072-6694/13/17/4401

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