Transgenic expression of the human LEDGF/p75 gene relieves the species barrier against HIV-1 infection in mouse cells

Transgenic expression of the human LEDGF/p75 gene relieves the species barrier against HIV-1 infection in mouse cells

Attempts to create mouse models for AIDS have been hampered by species barriers in HIV-1 infection. We previously showed that the nuclear accumulation of HIV-1 preintegration complex (PIC) was suppressed in mouse cells. Lens epithelium-derived growth factor (LEDGF/p75) is a host factor identified as...

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Bibliographic Details
Main Authors: Takuya eTada, Motohiko eKadoki, Liu eYang, Kenzo eTokunaga, Yoichiro eIwakura
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Microbiology
Subjects:
HIV-1
In
PIC
LEDGF/p75
nuclear accumulation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2013.00377/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2013.00377/full

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