p53 DNA Binding Cooperativity Is Essential for Apoptosis and Tumor Suppression In Vivo

p53 DNA Binding Cooperativity Is Essential for Apoptosis and Tumor Suppression In Vivo

Four molecules of the tumor suppressor p53 assemble to cooperatively bind proapoptotic target genes. The structural basis for cooperativity consists of interactions between adjacent DNA binding domains. Mutations at the interaction interface that compromise cooperativity were identified in cancer p...

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Bibliographic Details
Main Authors: Oleg Timofeev, Katharina Schlereth, Michael Wanzel, Attila Braun, Bernhard Nieswandt, Axel Pagenstecher, Andreas Rosenwald, Hans-Peter Elsässer, Thorsten Stiewe
Format: Article
Language:English
Published: Elsevier 2013-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713001757

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http://www.sciencedirect.com/science/article/pii/S2211124713001757

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