IFNγ Modulates the Immunopeptidome of Triple Negative Breast Cancer Cells by Enhancing and Diversifying Antigen Processing and Presentation

IFNγ Modulates the Immunopeptidome of Triple Negative Breast Cancer Cells by Enhancing and Diversifying Antigen Processing and Presentation

Peptide vaccination remains a viable approach to induce T-cell mediated killing of tumors. To identify potential T-cell targets for Triple-Negative Breast Cancer (TNBC) vaccination, we examined the effect of the pro-inflammatory cytokine interferon-γ (IFNγ) on the transcriptome, proteome, and immuno...

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Bibliographic Details
Main Authors: Gabriel Goncalves, Kerry A. Mullan, Divya Duscharla, Rochelle Ayala, Nathan P. Croft, Pouya Faridi, Anthony W. Purcell
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
mass spectrometry
immunopeptidomics
triple negative breast cancer
cytokine stimulation
human leukocyte antigen
transcriptomics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.645770/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.645770/full

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