Gliotoxin Induces Cofilin Phosphorylation to Promote Actin Cytoskeleton Dynamics and Internalization of Aspergillus fumigatus Into Type II Human Pneumocyte Cells

Gliotoxin Induces Cofilin Phosphorylation to Promote Actin Cytoskeleton Dynamics and Internalization of Aspergillus fumigatus Into Type II Human Pneumocyte Cells

Aspergillus fumigatus is able to internalize into lung epithelial cells to escape from immune attack for further dissemination. We previously reported that gliotoxin, a major mycotoxin of A. fumigatus, promotes this internalization; however, the mechanism remained unclear. Here, we report that gliot...

Full description

Bibliographic Details
Main Authors: Changjian Zhang, Fangyan Chen, Xiaoyu Liu, Xuelin Han, Yingsong Hu, Xueting Su, Yong Chen, Yansong Sun, Li Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Microbiology
Subjects:
gliotoxin
cofilin
actin cytoskeleton rearrangement
Aspergillus fumigatus
human pneumocyte cells
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.01345/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.01345/full

Similar Items