Forced Degradation Studies to Identify Critical Process Parameters for the Purification of Infectious Measles Virus

Forced Degradation Studies to Identify Critical Process Parameters for the Purification of Infectious Measles Virus

Oncolytic measles virus (MV) is a promising treatment for cancer but titers of up to 10<sup>11</sup> infectious particles per dose are needed for therapeutic efficacy, which requires an efficient, robust, and scalable production process. MV is highly sensitive to process conditions, and...

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Bibliographic Details
Main Authors: Daniel Loewe, Julian Häussler, Tanja A. Grein, Hauke Dieken, Tobias Weidner, Denise Salzig, Peter Czermak
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Viruses
Subjects:
temperature
pH
buffer
ionic strength
osmolality
isoelectric point
shear stress
Measles virus
stability
Online Access:https://www.mdpi.com/1999-4915/11/8/725

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https://www.mdpi.com/1999-4915/11/8/725

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