Synthesis of legonmycins A and B, C(7a)-hydroxylated bacterial pyrrolizidines

Synthesis of legonmycins A and B, C(7a)-hydroxylated bacterial pyrrolizidines

A one-flask, two-step procedure from 3-amino-2-methyl-5,6,7,7a-tetrahydro-1H-pyrrolizin-1-one affords the Streptomyces secondary metabolites legonmycins A and B – three operations overall from methyl N-Boc-prolinate. The key step proceeds in each case via N,O-diacylation, then selective oxidative hy...

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Bibliographic Details
Main Authors: Wilfred J. M. Lewis, David M. Shaw, Jeremy Robertson
Format: Article
Language:English
Published: Beilstein-Institut 2021-02-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
acyloxypyrroles
bacterial pyrrolizidines
cyanoketones
legonmycin
vinylogous ureas
Online Access:https://doi.org/10.3762/bjoc.17.31

Internet

https://doi.org/10.3762/bjoc.17.31

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