Molecular interaction of a kinase inhibitor midostaurin with anticancer drug targets, S100A8 and EGFR: transcriptional profiling and molecular docking study for kidney cancer therapeutics.

Molecular interaction of a kinase inhibitor midostaurin with anticancer drug targets, S100A8 and EGFR: transcriptional profiling and molecular docking study for kidney cancer therapeutics.

The S100A8 and epidermal growth factor receptor (EGFR) proteins are proto-oncogenes that are strongly expressed in a number of cancer types. EGFR promotes cellular proliferation, differentiation, migration and survival by activating molecular pathways. Involvement of proinflammatory S100A8 in tumor...

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Bibliographic Details
Main Authors: Zeenat Mirza, Hans-Juergen Schulten, Hasan Ma Farsi, Jaudah A Al-Maghrabi, Mamdooh A Gari, Adeel Ga Chaudhary, Adel M Abuzenadah, Mohammed H Al-Qahtani, Sajjad Karim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4366044?pdf=render

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http://europepmc.org/articles/PMC4366044?pdf=render

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