Synthetic DNA Vaccines Adjuvanted with pIL-33 Drive Liver-Localized T Cells and Provide Protection from <i>Plasmodium</i> Challenge in a Mouse Model

Synthetic DNA Vaccines Adjuvanted with pIL-33 Drive Liver-Localized T Cells and Provide Protection from <i>Plasmodium</i> Challenge in a Mouse Model

The need for a malaria vaccine is indisputable. A single vaccine for <i>Plasmodium</i> pre-erythrocytic stages targeting the major sporozoite antigen circumsporozoite protein (CSP) has had partial success. Additionally, CD8+ T cells targeting liver-stage (LS) antigens induced by live att...

Full description

Bibliographic Details
Main Authors: Sophia M. Reeder, Emma L. Reuschel, Mamadou A. Bah, Kun Yun, Nicholas J. Tursi, Kevin Y. Kim, Jacqueline Chu, Faraz I. Zaidi, Ilknur Yilmaz, Robert J. Hart, Benjamin Perrin, Ziyang Xu, Laurent Humeau, David B. Weiner, Ahmed S. I. Aly
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Vaccines
Subjects:
malaria
<i>plasmodium</i>
liver stage
exported proteins
dna vaccines
Online Access:https://www.mdpi.com/2076-393X/8/1/21

Internet

https://www.mdpi.com/2076-393X/8/1/21

Similar Items