Striatal Volume Increase After Six Weeks of Selective Dopamine D2/3 Receptor Blockade in First-Episode, Antipsychotic-Naïve Schizophrenia Patients

Striatal Volume Increase After Six Weeks of Selective Dopamine D2/3 Receptor Blockade in First-Episode, Antipsychotic-Naïve Schizophrenia Patients

Patients with chronic schizophrenia often display enlarged striatal volumes, and antipsychotic drugs may contribute via the dopamine D2/3 receptor (D2/3R) blockade. Separating the effects of disease from medication is challenging due to the lack of a proper placebo-group. To address this, we conduct...

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Bibliographic Details
Main Authors: Helle G. Andersen, Jayachandra M. Raghava, Claus Svarer, Sanne Wulff, Louise B. Johansen, Patrick K. Antonsen, Mette Ø. Nielsen, Egill Rostrup, Anthony C. Vernon, Lars T. Jensen, Lars H. Pinborg, Birte Y. Glenthøj, Bjørn H. Ebdrup
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Neuroscience
Subjects:
schizophrenia
dopamine receptor
first-episode antipsychotic-naïve
striatum
SPECT
sMRI
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00484/full

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https://www.frontiersin.org/article/10.3389/fnins.2020.00484/full

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