Donor-Derived Myeloid Heme Oxygenase-1 Controls the Development of Graft-Versus-Host Disease

Donor-Derived Myeloid Heme Oxygenase-1 Controls the Development of Graft-Versus-Host Disease

Graft-versus-host disease (GVHD) remains a major clinical drawback of allogeneic hematopoietic stem cell transplantation (HSCT). Here, we investigated how the stress responsive heme catabolizing enzyme heme oxygenase-1 (HO-1, encoded by HMOX1) regulates GVHD in response to allogeneic hematopoietic s...

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Bibliographic Details
Main Authors: Chloé Spilleboudt, Virginie De Wilde, Philippe Lewalle, Ludovic Cabanne, Mathieu Leclerc, Florence Beckerich, Dominique Bories, Silvia Cardoso, Miguel P. Soares, Benoît Vokaer, Jean-Michel Hougardy, Véronique Flamand, Judith Racapé, Marc Abramowicz, Sébastien Maury, Alain Le Moine
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
Heme oxygenase-1
graft-versus-host disease
transplantation
hematopoeietic stem cell transplantation
polymorphism
myeloid-derived suppressor cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.579151/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.579151/full

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