Hearing loss and hair cell death in mice given the cholesterol-chelating agent hydroxypropyl-β-cyclodextrin.

Hearing loss and hair cell death in mice given the cholesterol-chelating agent hydroxypropyl-β-cyclodextrin.

Cyclodextrins are sugar compounds that are increasingly finding medicinal uses due to their ability to complex with hydrophobic molecules. One cyclodextrin in particular, 2-hydroxypropyl-β-cyclodextrin (HPβCD), is used as a carrier to solubilize lipophilic drugs and is itself being considered as a t...

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Bibliographic Details
Main Authors: Mark A Crumling, Liqian Liu, Paul V Thomas, Jennifer Benson, Ariane Kanicki, Lisa Kabara, Karin Hälsey, David Dolan, R Keith Duncan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3532434?pdf=render

Internet

http://europepmc.org/articles/PMC3532434?pdf=render

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