Molecular Alterations in Sporadic and <i>SOD1</i>-ALS Immortalized Lymphocytes: Towards a Personalized Therapy

Molecular Alterations in Sporadic and <i>SOD1</i>-ALS Immortalized Lymphocytes: Towards a Personalized Therapy

Amyotrophic lateral sclerosis (ALS) is a fatal neurological condition where motor neurons (MNs) degenerate. Most of the ALS cases are sporadic (sALS), whereas 10% are hereditarily transmitted (fALS), among which mutations are found in the gene that codes for the enzyme superoxide dismutase 1 (SOD1)....

Full description

Bibliographic Details
Main Authors: Isabel Lastres-Becker, Gracia Porras, Marina Arribas-Blázquez, Inés Maestro, Daniel Borrego-Hernández, Patricia Boya, Sebastián Cerdán, Alberto García-Redondo, Ana Martínez, Ángeles Martin-Requero
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
amyotrophic lateral sclerosis
lymphoblast
oxidative stress
bioenergetic metabolism
NRF2
inflammation
Online Access:https://www.mdpi.com/1422-0067/22/6/3007

Internet

https://www.mdpi.com/1422-0067/22/6/3007

Similar Items