Correlation between ABCB1 gene polymorphisms, antiepileptic drug concentrations and treatment response

Correlation between ABCB1 gene polymorphisms, antiepileptic drug concentrations and treatment response

Aim: A possible molecular mechanism of clinically defined multidrug-resistant epilepsy involves drug efflux transporters such as P glycoprotein (P-gp), a member of the ATP-binding cassette subfamily B1 (ABCB1). We have investigated the prevalence of the C3435T, G 2677T/A, and T129C single-nucleotide...

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Bibliographic Details
Main Authors: Sabin Octavia, Bocșan Ioana Corina, Trifa Adrian, Major Zoltan Zsigmond, Heghes Simona Codruta, Bota Emanuela Brusturean, Buzoianu Anca Dana
Format: Article
Language:English
Published: Sciendo 2018-10-01
Series:Romanian Journal of Laboratory Medicine
Subjects:
mdr1
antiepileptic drugs
polymorphism
non-responders
p-glycoprotein
Online Access:https://doi.org/10.2478/rrlm-2018-0012

Internet

https://doi.org/10.2478/rrlm-2018-0012

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