Calpains mediate axonal cytoskeleton disintegration during Wallerian degeneration

Calpains mediate axonal cytoskeleton disintegration during Wallerian degeneration

In both the central nervous system (CNS) and peripheral nervous system (PNS), transected axons undergo Wallerian degeneration. Even though Augustus Waller first described this process after transection of axons in 1850, the molecular mechanisms may be shared, at least in part, by many human diseases...

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Bibliographic Details
Main Authors: Marek Ma, Toby A. Ferguson, Kathleen M. Schoch, Jian Li, Yaping Qian, Frances S. Shofer, Kathryn E. Saatman, Robert W. Neumar
Format: Article
Language:English
Published: Elsevier 2013-08-01
Series:Neurobiology of Disease
Subjects:
Axon
Calpain
Calpastatin
Neurofilament
Neuromuscular junction
Wallerian degeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113000971

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http://www.sciencedirect.com/science/article/pii/S0969996113000971

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