A Conserved Requirement for Fbxo7 During Male Germ Cell Cytoplasmic Remodeling

A Conserved Requirement for Fbxo7 During Male Germ Cell Cytoplasmic Remodeling

Fbxo7 is the substrate-recognition subunit of an SCF-type ubiquitin E3 ligase complex. It has physiologically important functions in regulating mitophagy, proteasome activity and the cell cycle in multiple cell types, like neurons, lymphocytes and erythrocytes. Here, we show that in addition to the...

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Bibliographic Details
Main Authors: Claudia C. Rathje, Suzanne J. Randle, Sara Al Rawi, Benjamin M. Skinner, David E. Nelson, Antara Majumdar, Emma E. P. Johnson, Joanne Bacon, Myrto Vlazaki, Nabeel A. Affara, Peter J. Ellis, Heike Laman
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Physiology
Subjects:
Fbxo7
PI31
proteasome
spermatogenesis
cell remodeling
germ cell
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01278/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.01278/full

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