MKP-4 suppresses hepatocarcinogenesis by targeting ERK1/2 pathway

MKP-4 suppresses hepatocarcinogenesis by targeting ERK1/2 pathway

Abstract Background Mitogen-activated protein kinase phosphatases-4 (MKP-4) is reported to exert a prognostic merit in hepatocarcinogenesis. However, the underlying molecular mechanisms have not been clearly defined. Methods Immunoprecipitation-mass spectrometry (IP-MS) approach was used to identify...

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Bibliographic Details
Main Authors: Zhongyi Shen, Chengliang Zhang, Lishuai Qu, Cuihua Lu, Mingbing Xiao, Runzhou Ni, Jinxia Liu
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Cancer Cell International
Subjects:
MKP-4
ERK1/2
Hepatocellular carcinoma
Phosphorylation
Prognosis
Online Access:http://link.springer.com/article/10.1186/s12935-019-0776-3

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http://link.springer.com/article/10.1186/s12935-019-0776-3

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