Loss of C/EBPδ Exacerbates Radiation-Induced Cognitive Decline in Aged Mice due to Impaired Oxidative Stress Response

Loss of C/EBPδ Exacerbates Radiation-Induced Cognitive Decline in Aged Mice due to Impaired Oxidative Stress Response

Aging is characterized by increased inflammation and deterioration of the cellular stress responses such as the oxidant/antioxidant equilibrium, DNA damage repair fidelity, and telomeric attrition. All these factors contribute to the increased radiation sensitivity in the elderly as shown by epidemi...

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Bibliographic Details
Main Authors: Sudip Banerjee, Tyler Alexander, Debajyoti Majumdar, Thomas Groves, Frederico Kiffer, Jing Wang, Akshita Gorantla, Antiño R. Allen, Snehalata A. Pawar
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:International Journal of Molecular Sciences
Subjects:
Cebpd
C/EBPδ
ionizing radiation
hippocampus
behavior
novel object recognition
spatial learning
short-term memory
oxidative stress
reactive oxygen species
Online Access:https://www.mdpi.com/1422-0067/20/4/885

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https://www.mdpi.com/1422-0067/20/4/885

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