The ocular toxicity and pharmacokinetics of simvastatin following intravitreal injection in mice

AIM: To investigate the retinal toxicity and pharmacokinetics of simvastatin intravitreally injected into mice. METHODS: Forty-eight 6-8-week-old C57BL/6J mice were used in this study. Simvastatin was intravitreally injected into the right eye of each mouse; the left eye was injected with vehicle a...

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Bibliographic Details
Main Authors: Dennis Y. Tse, Seong Jae Kim, Inyoung Chung, Feng He, Theodore G. Wensel, Samuel M. Wu
Format: Article
Language:English
Published: Press of International Journal of Ophthalmology (IJO PRESS) 2017-09-01
Series:International Journal of Ophthalmology
Subjects:
Online Access:http://www.ijo.cn/en_publish/2017/9/20170905.pdf