Decoding the Molecular Effects of Atovaquone Linked Resistant Mutations on <i>Plasmodium falciparum</i> Cytb-ISP Complex in the Phospholipid Bilayer Membrane

Decoding the Molecular Effects of Atovaquone Linked Resistant Mutations on <i>Plasmodium falciparum</i> Cytb-ISP Complex in the Phospholipid Bilayer Membrane

Atovaquone (ATQ) is a drug used to prevent and treat malaria that functions by targeting the <i>Plasmodium falciparum</i> cytochrome b (PfCytb) protein. PfCytb catalyzes the transmembrane electron transfer (ET) pathway which maintains the mitochondrial membrane potential. The ubiquinol s...

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Bibliographic Details
Main Authors: Lorna Chebon-Bore, Taremekedzwa Allan Sanyanga, Colleen Varaidzo Manyumwa, Afrah Khairallah, Özlem Tastan Bishop
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Plasmodium falciparum</i> cytochrome bc<sub>1</sub> complex
MD simulations
ATQ resistance
POPC:POPE phospholipid bilayer
heme and [2FE-2S] (rieske) cluster cofactors
dynamic residue network analysis
Online Access:https://www.mdpi.com/1422-0067/22/4/2138

Internet

https://www.mdpi.com/1422-0067/22/4/2138

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