Generation and Characterization of Mice Expressing a Conditional Allele of the Interleukin-1 Receptor Type 1.

Generation and Characterization of Mice Expressing a Conditional Allele of the Interleukin-1 Receptor Type 1.

The cytokines IL-1α and IL-1β exert powerful pro-inflammatory actions throughout the body, mediated primarily by the intracellular signaling capacity of the interleukin-1 receptor (IL-1R1). Although Il1r1 knockout mice have been informative with respect to a requirement for IL-1R1 signaling in infla...

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Bibliographic Details
Main Authors: Matthew J Robson, Chong-Bin Zhu, Meagan A Quinlan, David A Botschner, Nicole L Baganz, Kathryn M Lindler, Jason G Thome, William A Hewlett, Randy D Blakely
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4773179?pdf=render

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http://europepmc.org/articles/PMC4773179?pdf=render

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