<i>N</i>-(2-Hydroxy)-propyl-3-trimethylammonium, <i>O</i>-Mysristoyl Chitosan Enhances the Solubility and Intestinal Permeability of Anticancer Curcumin

<i>N</i>-(2-Hydroxy)-propyl-3-trimethylammonium, <i>O</i>-Mysristoyl Chitosan Enhances the Solubility and Intestinal Permeability of Anticancer Curcumin

An amphiphilic derivative of chitosan containing quaternary ammonium and myristoyl groups, herein named as ammonium myristoyl chitosan (DMCat), was synthesized by reacting glycidyltrimethylammonium chloride (GTMAC) and myristoyl chitosan (DMCh). The success of the modification was confirmed using Fo...

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Bibliographic Details
Main Authors: Daniella S. Silva, Danilo M. dos Santos, Andreia Almeida, Leonardo Marchiori, Sérgio P. Campana-Filho, Sidney J. L. Ribeiro, Bruno Sarmento
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Pharmaceutics
Subjects:
chitosan derivatives
amphiphilic polymers
polymeric micelles
quaternization
curcumin
intestinal delivery
Online Access:https://www.mdpi.com/1999-4923/10/4/245

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https://www.mdpi.com/1999-4923/10/4/245

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