hmSOD1 gene mutation‐induced disturbance in iron metabolism is mediated by impairment of Akt signalling pathway

hmSOD1 gene mutation‐induced disturbance in iron metabolism is mediated by impairment of Akt signalling pathway

Abstract Background Recently, skeletal muscle atrophy, impairment of iron metabolism, and insulin signalling have been reported in rats suffering from amyotrophic lateral sclerosis (ALS). However, the interrelationship between these changes has not been studied. We hypothesize that an impaired Akt–F...

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Bibliographic Details
Main Authors: Malgorzata Halon‐Golabek, Andzelika Borkowska, Jan J. Kaczor, Wieslaw Ziolkowski, Damian J. Flis, Narcyz Knap, Kajetan Kasperuk, Jedrzej Antosiewicz
Format: Article
Language:English
Published: Wiley 2018-06-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
ALS
Oxidative stress
p66Shc
Ferritin
FOXO3a
Muscle iron metabolism
Online Access:https://doi.org/10.1002/jcsm.12283

Internet

https://doi.org/10.1002/jcsm.12283

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