Mitochondrial Molecular Abnormalities Revealed by Proteomic Analysis of Hippocampal Organelles of Mice Triple Transgenic for Alzheimer Disease

Mitochondrial Molecular Abnormalities Revealed by Proteomic Analysis of Hippocampal Organelles of Mice Triple Transgenic for Alzheimer Disease

Mitochondrial dysfunction is implicated in the pathogenesis of Alzheimer’s disease (AD). However, the precise mitochondrial molecular deficits in AD remain poorly understood. Mitochondrial and nuclear proteomic analysis in mature male triple transgenic AD mice (PS1M146V/APPSwe/TauP301L) by two-dimen...

Full description

Bibliographic Details
Main Authors: Haitao Yu, Xuemei Lin, Dian Wang, Zaijun Zhang, Yi Guo, Xiaohu Ren, Benhong Xu, Jianhui Yuan, Jianjun Liu, Peter S. Spencer, Jian-Zhi Wang, Xifei Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Alzheimer’s disease (AD)
mitochondrial/nuclear proteomics
biomarkers
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00074/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2018.00074/full

Similar Items