Discovery and translation of a target engagement marker for AMP-activated protein kinase (AMPK).

Discovery and translation of a target engagement marker for AMP-activated protein kinase (AMPK).

BACKGROUND:Activation of the AMP-activated protein kinase (AMPK) is an attractive approach for the treatment of type 2 diabetes. AMPK activation reduces glucose levels in animal models of type 2 diabetes by increasing glucose uptake in skeletal muscles and reducing hepatic glucose production. Furthe...

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Main Authors: Rolf Grempler, Michael Wolff, Eric Simon, Ramona Schmid, Claudia Eisele, Kathrin Rieber, Elke Fischer, Sonja Mettel, Ogsen Gabrielyan, Denis Delic, Gerd Luippold, Norbert Redeman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5969744?pdf=render

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http://europepmc.org/articles/PMC5969744?pdf=render

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