A bcl-xS Adenovirus Selectively Induces Apoptosis in Transformed Cells Compared to Normal Mammary Cells

A bcl-xS Adenovirus Selectively Induces Apoptosis in Transformed Cells Compared to Normal Mammary Cells

Oncogenes which drive the cell cycle, such as c-myc, can sensitize cells to apoptosis. This suggests the possibility that the expression of genes such as bcl-2 or bcl-xL is required to inhibit apoptosis induced by oncogene expression. We hypothesized that inhibition of Bcl-2/Bcl-xL by the pro-apopt...

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Bibliographic Details
Main Authors: Venil N. Sumantran, David S. Lee, Kathleen M. Woods Ignatoski, Stephen P. Ethiert, Max S. Wicha
Format: Article
Language:English
Published: Elsevier 2000-05-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
apoptosis
bcl-xS
mammary cells
c-erbB-2
normal
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558600800342

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http://www.sciencedirect.com/science/article/pii/S1476558600800342

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