Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement

Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement

Properdin stabilizes the alternative C3 convertase (C3bBb), whereas its role as pattern-recognition molecule mediating complement activation is disputed for decades. Previously, we have found that soluble collectin-12 (sCL-12) synergizes complement alternative pathway (AP) activation. However, wheth...

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Bibliographic Details
Main Authors: Jie Zhang, Lihong Song, Dennis V Pedersen, Anna Li, John D Lambris, Gregers Rom Andersen, Tom Eirik Mollnes, Ying Jie Ma, Peter Garred
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
collectin-12
properdin
alternative pathway
the complement system
Online Access:https://elifesciences.org/articles/60908

Internet

https://elifesciences.org/articles/60908

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