The association of APOE ε4 with cognitive function over the adult life course and incidence of dementia: 20 years follow-up of the Whitehall II study

The association of APOE ε4 with cognitive function over the adult life course and incidence of dementia: 20 years follow-up of the Whitehall II study

Abstract Background Approximately 25% of the general population carries at least one ε4 allele of the Apolipoprotein E (APOE ε4), the strongest genetic risk factor for late onset Alzheimer’s disease. Beyond its association with late-onset dementia, the association between APOE ε4 and change in cogni...

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Bibliographic Details
Main Authors: Amin Gharbi-Meliani, Aline Dugravot, Séverine Sabia, Melina Regy, Aurore Fayosse, Alexis Schnitzler, Mika Kivimäki, Archana Singh-Manoux, Julien Dumurgier
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Alzheimer’s Research & Therapy
Subjects:
Apolipoprotein E
Cognitive aging
Cohort study
Dementia
Alzheimer’s disease
Online Access:https://doi.org/10.1186/s13195-020-00740-0

Internet

https://doi.org/10.1186/s13195-020-00740-0

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