Antitrypanosomal Activity of Sesquiterpene Lactones from Helianthus tuberosus L. Including a New Furanoheliangolide with an Unusual Structure

Antitrypanosomal Activity of Sesquiterpene Lactones from Helianthus tuberosus L. Including a New Furanoheliangolide with an Unusual Structure

As part of our efforts to exploit the antitrypanosomal potential of sesquiterpene lactones (STL) from Helianthus tuberosus L. (Asteraceae), besides the known 4,15-iso-atriplicolide tiglate, -methacrylate and -isobutyrate, a hitherto unknown STL was isolated. Its structure was solved by extensive NMR...

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Bibliographic Details
Main Authors: Anna Galkina, Nico Krause, Mairin Lenz, Constantin G. Daniliuc, Marcel Kaiser, Thomas J. Schmidt
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Molecules
Subjects:
sesquiterpene lactone
furanoheliangolide
X-ray crystallography
antiprotozoal activity
Trypanosoma brucei rhodesiense
Trypanosoma cruzi
Leishmania donovani
Plasmodium falciparum
cytotoxicity
Online Access:http://www.mdpi.com/1420-3049/24/6/1068

Internet

http://www.mdpi.com/1420-3049/24/6/1068

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