Structural basis for the coiled-coil architecture of human CtIP

Structural basis for the coiled-coil architecture of human CtIP

The DNA repair factor CtIP has a critical function in double-strand break (DSB) repair by homologous recombination, promoting the assembly of the repair apparatus at DNA ends and participating in DNA-end resection. However, the molecular mechanisms of CtIP function in DSB repair remain unclear. Here...

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Bibliographic Details
Main Authors: C. R. Morton, N. J. Rzechorzek, J. D. Maman, M. Kuramochi, H. Sekiguchi, R. Rambo, Y. C. Sasaki, O. R. Davies, L. Pellegrini
Format: Article
Language:English
Published: The Royal Society 2021-06-01
Series:Open Biology
Subjects:
human CtIP
DNA repair
coiled-coil structure
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.210060

Internet

https://royalsocietypublishing.org/doi/10.1098/rsob.210060

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