Motility and microtubule depolymerization mechanisms of the Kinesin-8 motor, KIF19A

Motility and microtubule depolymerization mechanisms of the Kinesin-8 motor, KIF19A

The kinesin-8 motor, KIF19A, accumulates at cilia tips and controls cilium length. Defective KIF19A leads to hydrocephalus and female infertility because of abnormally elongated cilia. Uniquely among kinesins, KIF19A possesses the dual functions of motility along ciliary microtubules and depolymeriz...

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Bibliographic Details
Main Authors: Doudou Wang, Ryo Nitta, Manatsu Morikawa, Hiroaki Yajima, Shigeyuki Inoue, Hideki Shigematsu, Masahide Kikkawa, Nobutaka Hirokawa
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-09-01
Series:eLife
Subjects:
kinesin
X-ray crystallography
microtubule dynamic
cryo-electron microscopy
Online Access:https://elifesciences.org/articles/18101

Internet

https://elifesciences.org/articles/18101

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