Huangqi Decoction Alleviates Alpha-Naphthylisothiocyanate Induced Intrahepatic Cholestasis by Reversing Disordered Bile Acid and Glutathione Homeostasis in Mice

Huangqi Decoction Alleviates Alpha-Naphthylisothiocyanate Induced Intrahepatic Cholestasis by Reversing Disordered Bile Acid and Glutathione Homeostasis in Mice

Intrahepatic cholestasis is a serious symptom of liver disorders with limited therapies. In this study, we investigated the efficacy of Huangqi decoction (HQD), a two-herb classic traditional Chinese medicine (TCM), in the treatment of alpha-naphthylisothiocyanate (ANIT)-induced intrahepatic cholest...

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Bibliographic Details
Main Authors: Jia-Sheng Wu, Yi-Fei Li, Yuan-Yuan Li, Yan Dai, Wen-Kai Li, Min Zheng, Zheng-Chun Shi, Rong Shi, Tian-Ming Wang, Bing-Liang Ma, Ping Liu, Yue-Ming Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Pharmacology
Subjects:
intrahepatic cholestasis
Huangqi decoction
traditional Chinese medicine
Nrf2
metabolomics
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00938/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00938/full

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