Transient Astrocytic Gq Signaling Underlies Remote Memory Enhancement

Transient Astrocytic Gq Signaling Underlies Remote Memory Enhancement

Astrocytes elicit transient Ca2+ elevations induced by G protein-coupled receptors (GPCRs), yet their role in vivo remains unknown. To address this, transgenic mice with astrocytic expression of the optogenetic Gq-type GPCR, Optoα1AR, were established, in which transient Ca2+ elevations similar to t...

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Bibliographic Details
Main Authors: Youichi Iwai, Katsuya Ozawa, Kazuko Yahagi, Tsuneko Mishima, Sonam Akther, Camilla Trang Vo, Ashley Bomin Lee, Mika Tanaka, Shigeyoshi Itohara, Hajime Hirase
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Neural Circuits
Subjects:
astrocytes
optogenetic activation
G protein-coupled receptor
Ca2+ signaling
memory
OptoA1AR
Online Access:https://www.frontiersin.org/articles/10.3389/fncir.2021.658343/full

Internet

https://www.frontiersin.org/articles/10.3389/fncir.2021.658343/full

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