Exosomal Tumor MicroRNA Modulates Premetastatic Organ Cells

Tumor exosomes educate selected host tissues toward a prometastatic phenotype. We demonstrated this for exosomes of the metastatic rat adenocarcinoma BSp73ASML (ASML), which modulate draining lymph nodes and lung tissue to support settlement of poorly metastatic BSp73ASML-CD44v4-v7 knockdown (ASML-...

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Bibliographic Details
Main Authors: Sanyukta Rana, Kamilla Malinowska, Margot Zöller
Format: Article
Language:English
Published: Elsevier 2013-03-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558613800577