An oxidative stress mechanism of shikonin in human glioma cells.

Shikonin is a quinone-containing natural product that induces the apoptotic death of some cancer cell lines in culture through increasing intracellular reactive oxygen species (ROS). Quinone-based drugs have shown potential in the clinic, making shikonin an interesting compound to study. Our previou...

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Bibliographic Details
Main Authors: Jen-Tsung Yang, Zih-Ling Li, Jin-Yi Wu, Fung-Jou Lu, Ching-Hsein Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3979747?pdf=render