Endoplasmic reticulum tubules limit the size of misfolded protein condensates

Endoplasmic reticulum tubules limit the size of misfolded protein condensates

The endoplasmic reticulum (ER) is composed of sheets and tubules. Here we report that the COPII coat subunit, SEC24C, works with the long form of the tubular ER-phagy receptor, RTN3, to target dominant-interfering mutant proinsulin Akita puncta to lysosomes. When the delivery of Akita puncta to lyso...

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Bibliographic Details
Main Authors: Smriti Parashar, Ravi Chidambaram, Shuliang Chen, Christina R Liem, Eric Griffis, Gerard G Lambert, Nathan C Shaner, Matthew Wortham, Jesse C Hay, Susan Ferro-Novick
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-09-01
Series:eLife
Subjects:
ER-phagy
protein quality control
misfolded prohormones
SEC24C
Lunapark
ER structure
Online Access:https://elifesciences.org/articles/71642

Internet

https://elifesciences.org/articles/71642

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