Multi-Parameter Analysis of Biobanked Human Bone Marrow Stromal Cells Shows Little Influence for Donor Age and Mild Comorbidities on Phenotypic and Functional Properties

Multi-Parameter Analysis of Biobanked Human Bone Marrow Stromal Cells Shows Little Influence for Donor Age and Mild Comorbidities on Phenotypic and Functional Properties

Heterogeneous populations of human bone marrow-derived stromal cells (BMSC) are among the most frequently tested cellular therapeutics for treating degenerative and immune disorders, which occur predominantly in the aging population. Currently, it is unclear whether advanced donor age and commonly a...

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Bibliographic Details
Main Authors: Anastazja Andrzejewska, Rusan Catar, Janosch Schoon, Taimoor Hasan Qazi, Frauke Andrea Sass, Dorit Jacobi, Antje Blankenstein, Simon Reinke, David Krüger, Mathias Streitz, Stephan Schlickeiser, Sarina Richter, Naima Souidi, Christien Beez, Julian Kamhieh-Milz, Ulrike Krüger, Tomasz Zemojtel, Karsten Jürchott, Dirk Strunk, Petra Reinke, Georg Duda, Guido Moll, Sven Geissler
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
cellular therapy
bone marrow stromal cell
mesenchymal stromal cell
in vivo and in vitro aging
comorbidity
in vitro potency assay
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02474/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.02474/full

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