Comparison of mouse models reveals a molecular distinction between psychotic illness in PWS and schizophrenia

Abstract Prader-Willi Syndrome (PWS) is a neurodevelopmental disorder caused by mutations affecting paternal chromosome 15q11-q13, and characterized by hypotonia, hyperphagia, impaired cognition, and behavioural problems. Psychotic illness is a challenging problem for individuals with PWS and has di...

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Bibliographic Details
Main Authors: Simona K. Zahova, Trevor Humby, Jennifer R. Davies, Joanne E. Morgan, Anthony R. Isles
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-021-01561-x