A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington’s disease patients

A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington’s disease patients

Abstract Huntington’s disease (HD) is a progressive neurodegenerative disease. Involuntary movements, cognitive impairment and psychiatric disturbance are the major clinical manifestations, and gradual atrophy and selective neuronal loss in the striatum and cerebral cortex are the pathologic hallmar...

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Bibliographic Details
Main Authors: Peng Liu, Benjamin R. Smith, Eric S. Huang, Abhishek Mahesh, Jean Paul G. Vonsattel, Ashley J. Petersen, Rocio Gomez-Pastor, Karen H. Ashe
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Acta Neuropathologica Communications
Subjects:
Microtubule-associated protein tau
Caspase-2
Huntingtin
Frontal cortex
Caudate nucleus
Striatum
Online Access:http://link.springer.com/article/10.1186/s40478-019-0764-9

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http://link.springer.com/article/10.1186/s40478-019-0764-9

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