Molecular Changes Induced in Melanoma by Cell Culturing in 3D Alginate Hydrogels

Molecular Changes Induced in Melanoma by Cell Culturing in 3D Alginate Hydrogels

Alginate hydrogels have been used as a biomaterial for 3D culturing for several years. Here, gene expression patterns in melanoma cells cultivated in 3D alginate are compared to 2D cultures. It is well-known that 2D cell culture is not resembling the complex in vivo situation well. However, the use...

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Bibliographic Details
Main Authors: Melanie Kappelmann-Fenzl, Sonja K. Schmidt, Stefan Fischer, Rafael Schmid, Lisa Lämmerhirt, Lena Fischer, Stefan Schrüfer, Ingo Thievessen, Dirk W. Schubert, Alexander Matthies, Rainer Detsch, Aldo R. Boccaccini, Andreas Arkudas, Annika Kengelbach-Weigand, Anja K. Bosserhoff
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
melanoma
biomaterials
3D cultivation
whole transcriptome
EGR1
Online Access:https://www.mdpi.com/2072-6694/13/16/4111

Internet

https://www.mdpi.com/2072-6694/13/16/4111

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