Renal neoplasms in tuberous sclerosis mice are neurocristopathies

Summary: Tuberous sclerosis (TS) is a rare disorder exhibiting multi-systemic benign neoplasms. We hypothesized the origin of TS neoplastic cells derived from the neural crest given the heterogeneous ecto-mesenchymal phenotype of the most common TS neoplasms. To test this hypothesis, we employed Cre...

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Bibliographic Details
Main Authors: Uchenna Unachukwu, Takayuki Shiomi, Monica Goldklang, Kiran Chada, Jeanine D'Armiento
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221006520