HIV Protease Inhibitors Decrease VEGF/HIF-1α Expression and Angiogenesis in Glioblastoma Cells

HIV Protease Inhibitors Decrease VEGF/HIF-1α Expression and Angiogenesis in Glioblastoma Cells

Glioblastomas are malignant brain tumors that are rarely curable, even with aggressive therapy (surgery, chemotherapy, radiation). Glioblastomas frequently display loss of PTEN and/or epidermal growth factor receptor activation, both of which activate the PI3K pathway. This pathway can increase vas...

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Bibliographic Details
Main Authors: Nabendu Pore, Anjali K. Gupta, George J. Cerniglia, Amit Maity
Format: Article
Language:English
Published: Elsevier 2006-11-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Nelfinavir
amprenavir
VEGF
HIF-1α
Akt
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558606800722

Internet

http://www.sciencedirect.com/science/article/pii/S1476558606800722

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