VLA-4 Induces Chemoresistance of T Cell Acute Lymphoblastic Leukemia Cells via PYK2-Mediated Drug Efflux

VLA-4 Induces Chemoresistance of T Cell Acute Lymphoblastic Leukemia Cells via PYK2-Mediated Drug Efflux

Cell adhesion plays a critical role in the development of chemoresistance, which is a major issue in anti-cancer therapies. In this study, we have examined the role of the VLA-4 integrin, a major adhesion molecule of the immune system, in the chemoresistance of T-ALL cells. We found that attachment...

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Bibliographic Details
Main Authors: Sofiane Berrazouane, Alexie Doucet, Marc Boisvert, Frédéric Barabé, Fawzi Aoudjit
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
VLA-4
VCAM-1
chemoresistance
T-cell acute lymphoblastic leukemia
PYK2
drug efflux
Online Access:https://www.mdpi.com/2072-6694/13/14/3512

Internet

https://www.mdpi.com/2072-6694/13/14/3512

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