Development of standard clinical endpoints for use in dengue interventional trials: introduction and methodology

Development of standard clinical endpoints for use in dengue interventional trials: introduction and methodology

Abstract Background As increasing numbers of dengue vaccines and therapeutics are in clinical development, standardized consensus clinical endpoint definitions are urgently needed to assess the efficacy of different interventions with respect to disease severity. We aimed to convene dengue experts r...

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Main Authors: Thomas Jaenisch, Kim Hendrickx, Martin Erpicum, Liane Agulto, Kay M. Tomashek, Walla Dempsey, João Bosco Siqueira, Morgan A. Marks, Michael P. Fay, Catherine Laughlin, Maina L’Azou, Yee-Sin Leo, Federico Narvaez, Remy Teyssou, Stephen J. Thomas, Hasitha Tissera, Derek Wallace, Annelies Wilder-Smith, Duane J. Gubler, M. Cristina Cassetti
Format: Article
Language:English
Published: BMC 2018-11-01
Series:BMC Medical Research Methodology
Subjects:
Dengue
Severe dengue
Endpoints
Standardization
Validation
DELPHI
Online Access:http://link.springer.com/article/10.1186/s12874-018-0601-z

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http://link.springer.com/article/10.1186/s12874-018-0601-z

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