Amelioration of High-Insulin-Induced Skeletal Muscle Cell Insulin Resistance by Resveratrol Is Linked to Activation of AMPK and Restoration of GLUT4 Translocation

Amelioration of High-Insulin-Induced Skeletal Muscle Cell Insulin Resistance by Resveratrol Is Linked to Activation of AMPK and Restoration of GLUT4 Translocation

Insulin resistance, the hallmark of type 2 diabetes mellitus (T2DM), is linked to hyperinsulinemia, which develops to counterbalance initial peripheral hormone resistance. Studies indicate that chronically elevated levels of insulin lead to skeletal muscle insulin resistance by deregulating steps wi...

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Bibliographic Details
Main Authors: Filip Vlavcheski, Danja J. Den Hartogh, Adria Giacca, Evangelia Tsiani
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Nutrients
Subjects:
resveratrol
high insulin
insulin resistance
IRS-1
mTOR
p70 S6K
Online Access:https://www.mdpi.com/2072-6643/12/4/914

Internet

https://www.mdpi.com/2072-6643/12/4/914

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