A Celecoxib Derivative Eradicates Antibiotic-Resistant <i>Staphylococcus aureus</i> and Biofilms by Targeting YidC2 Translocase

A Celecoxib Derivative Eradicates Antibiotic-Resistant <i>Staphylococcus aureus</i> and Biofilms by Targeting YidC2 Translocase

The treatment of <i>Staphylococcus aureus</i> infections is impeded by the prevalence of MRSA and the formation of persisters and biofilms. Previously, we identified two celecoxib derivatives, Cpd36 and Cpd46, to eradicate MRSA and other staphylococci. Through whole-genome resequencing,...

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Bibliographic Details
Main Authors:	Shiou-Ru Tzeng, Yi-Wei Huang, Yao-Qing Zhang, Ching-Yi Yang, Han-Sheng Chien, Yi-Ru Chen, Sung-Liang Yu, Ching S. Chen, Hao-Chieh Chiu
Format:	Article
Language:	English
Published:	MDPI AG 2020-12-01
Series:	International Journal of Molecular Sciences
Subjects:	MRSA translocon thermal shift surface plasmon resonance
Online Access:	https://www.mdpi.com/1422-0067/21/23/9312

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