Kinase-targeted cancer therapies: progress, challenges and future directions

Kinase-targeted cancer therapies: progress, challenges and future directions

Abstract The human genome encodes 538 protein kinases that transfer a γ-phosphate group from ATP to serine, threonine, or tyrosine residues. Many of these kinases are associated with human cancer initiation and progression. The recent development of small-molecule kinase inhibitors for the treatment...

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Bibliographic Details
Main Authors: Khushwant S. Bhullar, Naiara Orrego Lagarón, Eileen M. McGowan, Indu Parmar, Amitabh Jha, Basil P. Hubbard, H. P. Vasantha Rupasinghe
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Molecular Cancer
Subjects:
Kinases
Kinase inhibition
Small-molecule drugs
Cancer
Oncology
Online Access:http://link.springer.com/article/10.1186/s12943-018-0804-2

Internet

http://link.springer.com/article/10.1186/s12943-018-0804-2

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