Constitutively Elevated Blood Serotonin Is Associated with Bone Loss and Type 2 Diabetes in Rats.

Constitutively Elevated Blood Serotonin Is Associated with Bone Loss and Type 2 Diabetes in Rats.

Reduced peripheral serotonin (5HT) in mice lacking tryptophan hydroxylase (TPH1), the rate limiting enzyme for 5HT synthesis, was reported to be anabolic to the skeleton. However, in other studies TPH1 deletion either had no bone effect or an age dependent inhibition of osteoclastic bone resorption....

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Main Authors: Igor Erjavec, Tatjana Bordukalo-Niksic, Jelena Brkljacic, Danka Grcevic, Gordana Mokrovic, Maja Kesic, Dunja Rogic, William Zavadoski, Vishwas M Paralkar, Lovorka Grgurevic, Vladimir Trkulja, Lipa Cicin-Sain, Slobodan Vukicevic
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4764355?pdf=render

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http://europepmc.org/articles/PMC4764355?pdf=render

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