A protease-activated receptor 1 antagonist protects against global cerebral ischemia/reperfusion injury after asphyxial cardiac arrest in rabbits

A protease-activated receptor 1 antagonist protects against global cerebral ischemia/reperfusion injury after asphyxial cardiac arrest in rabbits

Cerebral ischemia/reperfusion injury is partially mediated by thrombin, which causes brain damage through protease-activated receptor 1 (PAR1). However, the role and mechanisms underlying the effects of PAR1 activation require further elucidation. Therefore, the present study investigated the effect...

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Bibliographic Details
Main Authors: Jing-ning Yang, Jun Chen, Min Xiao
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2017-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; protease-activated receptor 1; global cerebral ischemia/reperfusion; cardiac arrest; neuroprotection; SCH79797; apoptosis; inflammation; neuron specific enolase; hippocampus; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=2;spage=242;epage=249;aulast=Yang

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=2;spage=242;epage=249;aulast=Yang

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